Maternal exercise during pregnancy has been suggested to exert the beneficial effects on the brain functions of offspring. In the present study, we attempted to determine the effects of maternal treadmill running during pregnancy on short-term memory ...

Maternal exercise during pregnancy has been suggested to exert the beneficial effects on the brain functions of offspring. In the present study, we attempted to determine the effects of maternal treadmill running during pregnancy on short-term memory ability, hippocampal cell survival, and the expression of brain-derived neurotrophic factor (BDNF) mRNA in rat pups. After confirming pregnancy, the pregnant rats were divided into two groups: the control group and the running group (n = 6 in each group). Beginning on the 15th day of pregnancy, the pregnant rats in the running group were forced to run on a treadmill for 30 min at a mild-intensity, once a day until delivery. After all the pregnant rats had given birth, there were rat pups available for use in this study in each group (n = 15 in each group). The latency of the step-down avoidance task was used in order to evaluate the short-term memory ability of the rat pups on the 28 days after birth. Immunohistochemistry for 5-bromo-2'-deoxyuridine (BrdU) and reverse transcription-polymerase chain reaction (RT-PCR) for BDNF mRNA were performed to determine hippocampal neurogenesis and hippocampal BDNF mRNA expression of the rat pups on the 29 days after birth, respectively. Our results revealed that maternal running during pregnancy resulted in significant increase in the expression of BDNF mRNA, enhanced hippocampal cell survival, and improved the short-term memory capability of rat pups, as compared to those measured in the control group. The findings of our study provide evidence that maternal running during gestational period may enhance the brain functions of offspring.

<출처: WILEY Online Library, https://doi.org/10.1016/j.ijdevneu.2007.03.003>

본 자료는 최종결과물(결과보고서)의 원자료이다.

본 연구는 당뇨병 유발 동물모델에서 규칙적인 운동이 미치는 영향을 뇌 해마 부위의 분석을 통해 살펴보는 연구이다. 이를 위하여, 수동회피 검사를 본 자료인 Kim et al. (2007)의 선행연구에 따라 실시하였다.

본 자료는 최종결과물(결과보고서)의 원자료이다.

본 연구는 당뇨병 유발 동물모델에서 규칙적인 운동이 미치는 영향을 뇌 해마 부위의 분석을 통해 살펴보는 연구이다. 이를 위하여, 수동회피 검사를 본 자료인 Kim et al. (2007)의 선행연구에 따라 실시하였다.

1. Introduction
2. Experimental Procedures
2.1. Animals and treatments
2.2. Exercise protocol
2.3. Step-down avoidance task
2.4. Tissue preparation
2.5. BrdU immunohistochemistry
2.6. RNA isolation and RT-PCR
2.7. Data analysis
2.8. Statistical an ...

1. Introduction
2. Experimental Procedures
2.1. Animals and treatments
2.2. Exercise protocol
2.3. Step-down avoidance task
2.4. Tissue preparation
2.5. BrdU immunohistochemistry
2.6. RNA isolation and RT-PCR
2.7. Data analysis
2.8. Statistical analysis
3. Results
3.1. Effect of maternal running during pregnancy on stepdown avoidance task in rat pups
3.2. Effect of maternal running during pregnancy on neurogenesis in the dentate gyrus of the hippocampus of rat pups
3.3. Effect of maternal running during pregnancy on neurogenesis in the CA1 region of the hippocampus of rat pups
3.4. Effect of maternal running during pregnancy on neurogenesis in the CA2 and CA3 regions of the hippocampus of rat pups
4. Discussion
Acknowledgements
References