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BCAA 섭취가 골격근의 lactate transporter 발현과 젖산대사에 미치는 영향
Reports NRF is supported by Research Projects( BCAA 섭취가 골격근의 lactate transporter 발현과 젖산대사에 미치는 영향 | 2004 Year 신청요강 다운로드 PDF다운로드 | 임기원(건국대학교) ) data is submitted to the NRF Project Results
Researcher who has been awarded a research grant by Humanities and Social Studies Support Program of NRF has to submit an end product within 6 months(* depend on the form of business)
  • Researchers have entered the information directly to the NRF of Korea research support system
Project Number G00150
Year(selected) 2004 Year
the present condition of Project 종료
State of proposition 재단승인
Completion Date 2006년 04월 28일
Year type 결과보고
Year(final report) 2006년
Research Summary
  • Korean
  • 본 연구에서는 BCAA 섭취가 젖산수송체의 mRNA 발현에 미치는 영향과 젖산대사에 미치는 영향을 실험동물과 운동선수를 대상으로 검토하였다. 실험1(실험동물실험)에서는 40마리의 SD 숫컷rats을 대조군과 BCAA 섭취군으로 나누었다. BCAA 섭취군은 1일 체중 kg 당 1g의 BCAA를 4주간 섭취시켰다. 각 군의 반은 실험동물용 트레드밀에서 운동속도 25m/min, 경사 5도에서 1일 30분, 주5일간씩 4주간 운동을 부하하였다. 각 군의 Rats은 운동 0, 30 및 60분후 도살하여 비복근의 젖산수송체를 분석하였다. 실험2(운동선수실험)에서는 대학 운동선수 8명을 대상으로 체중 kg당 100mg의 BCAA를 투여한 후 60% VO2max 운동을 1시간부하하여 호기가스와 혈액을 채취하였다. 근육과 간의 글리코겐 농도는 BCAA 섭취에 의해 영향을 받지 않았다. 또한, MCT1 및 MCT4 mRNA 발현량도 BCAA 섭취에 영향을 받지 않았다. 그러나 운동은 유의하게 MCT1 및 MCT4 mRNA 발현량을 증가시켰다. 운동선수에서는 BCAA 섭취가 탄수화물/지방산화량, 혈액성분에는 영향을 미치지 않았지만 탈진에 도달하는 지구성 운동능력을 향상되었다. 따라서 본 연구결과를 고려하면 BCAA 는 말추피로에는 영향을 미치지 않지만 중추피로를 개선하여 지구성 운동능력을 향상시키는 것으로 평가되었다.
  • English
  • PURPOSE: The purpose of this study was to investigate the effect of branched chain amino acid (BCAA) ingestion on lactate transporter expression during endurance exercise in rats and athletes. METHODS: Experiment 1. Forty male Sprague-Dawley rats were divided into control and BCAA groups. Rats of BCAA group were administrated 1 g/kg bw (valine : leucine : isoleucine = 1 : 2: 1) for 4 weeks. Half of rats in each group were trained on a motor driven treadmill at 25 m/min, 5° incline, 30 min/day, 5 days/week for 4 weeks. The rats of each group were sacrificed at 0 min, 30 min and 60 min after treadmill running exercise at 25 m/min, 5° incline. Experiment 2. Athlete subjects were ingested 100mg/kg of BCAAs (valine : leucine : isoleucine=1:2:1) 1 hr prior to the exercise. They exercised on a cycle ergometer at 60% of their VO2max for 1 hr, and then the exercise intensity was increased at 80% of their VO2max until exhaustion. RESULTS: Glycogen contents in skeletal muscles and liver were not changed by BCAA ingestion during exercise. Also, mRNA expression of MCT1 and MCT4 in gastrocnemius muscle was not affected by BCAA ingestion in rats. However, the exercise training significantly increased mRNA expression of MCT1 and MCT4 in gastrocnemius muscle. The plasma BCAA levels were significantly higher in BCAA trial than in control trial during the exercise. Levels of lactate, FFA and TG in blood and carbohydrate and fat oxidation during exercise were not affected by BCAA ingestion. However, endurance capacity in BCAA trial was significantly higher than in control trial. CONCLUSION: These results suggest that BCAA ingestion should increased endurance exercise performance resulting from reduce of central fatigue in rats and athletes.
Research result report
  • Abstract
  • PURPOSE: The purpose of this study was to investigate the effect of branched chain amino acid (BCAA) ingestion on lactate transporter expression during endurance exercise in rats and athletes. METHODS: Experiment 1. Forty male Sprague-Dawley rats were divided into control and BCAA groups. Rats of BCAA group were administrated 1 g/kg bw (valine : leucine : isoleucine = 1 : 2: 1) for 4 weeks. Half of rats in each group were trained on a motor driven treadmill at 25 m/min, 5° incline, 30 min/day, 5 days/week for 4 weeks. The rats of each group were sacrificed at 0 min, 30 min and 60 min after treadmill running exercise at 25 m/min, 5° incline. Experiment 2. Athlete subjects were ingested 100mg/kg of BCAAs (valine : leucine : isoleucine=1:2:1) 1 hr prior to the exercise. They exercised on a cycle ergometer at 60% of their VO2max for 1 hr, and then the exercise intensity was increased at 80% of their VO2max until exhaustion. RESULTS: Glycogen contents in skeletal muscles and liver were not changed by BCAA ingestion during exercise. Also, mRNA expression of MCT1 and MCT4 in gastrocnemius muscle was not affected by BCAA ingestion in rats. However, the exercise training significantly increased mRNA expression of MCT1 and MCT4 in gastrocnemius muscle. The plasma BCAA levels were significantly higher in BCAA trial than in control trial during the exercise. Levels of lactate, FFA and TG in blood and carbohydrate and fat oxidation during exercise were not affected by BCAA ingestion. However, endurance capacity in BCAA trial was significantly higher than in control trial. CONCLUSION: These results suggest that BCAA ingestion should increased endurance exercise performance resulting from reduce of central fatigue in rats and athletes.
  • Research result and Utilization method
  • 본 연구결과는 운동과 영양 분야에 젖산수송체라는 근육의 에너지 기질 수송체의 분자생물학적 연구를 접목시키는 것으로 BCAA 섭취에 의해서는 말초피로 인자인 젖산대사에 영향을 미치지 않았지만 향후 젖산수송체와 운동과의 관계는 스포츠과학분야에서 매우 중요한 연구주제로 부각될 가능성이 있으며 이에 대한 면밀한 연구가 요청된다.
  • Index terms
  • MCT1, MCT4, BCAA, lactate, lactate transporter, exercise
  • List of digital content of this reports
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